INFLAMMATION:
We all have inflammation every day. When our tissues get damaged or even irritated, our body sends immune cells to the area to launch an attack on whatever’s causing trouble. This is what an inflammatory response is, and it causes redness, swelling and pain.
Inflammation is usually caused by a temporary trigger -- a virus causing a sore throat or stubbing your toe, the inflammation goes away once the area is healed. Inflammation can also be caused by more subtle things like the food we eat and toxins that we touch. These small things can irritate our body and trigger a small immune response. When these triggers happen often and are part of our usual routine, the inflammation can become chronic.
CHRONIC INFLAMMATION:
When we trigger and re trigger an inflammatory response, we develop chronic inflammation. Chronic inflammation is bad for your body. Chronic inflammation can make you tired and achey and is related to chronic disease like diabetes, cancer, dementia, depression, and obesity.
What should we do about it? Lets find its causes.
DIET, INACTIVITY, AND TOXINS CAUSE CHRONIC INFLAMMATION:
Consuming excessive calories or sugars, salt, alcohol, and saturated or trans fats can trigger inflammation. The absence of fiber and nutrients in the diet can also trigger inflammation. Mediterranean diets, which are high in plant-based foods, omega-3 fatty acids, and healthy fats, can help fight inflammation. Certain very specific types of fasts are being studied to measure the impact on decreasing inflammation.
Under working your body can cause inflammation. No matter what your weight, being sedentary causes inflammation. The specific mechanisms linking being sedentary and inflammation are still unclear.
Smoking and air pollutants can impact inflammatory markers. A common exposure are the many common household cleaning products that contain high amounts of toxins that can trigger inflammation.
DETECTING AND FIGHTING CHRONIC INFLAMMATION:
Detecting chronic inflammation can be difficult without looking to your actual blood markers, as many sufferers might not yet present any physical symptoms. Several blood markers can indicate chronic inflammation, such as high-sensitivity C-reactive protein, a substance formed by the liver in response to inflammation, and IL-8, a protein involved in systemic inflammation. Furthermore, you can also be genetically predisposed to chronic inflammation.
Whether or not you have high inflammation markers, the steps to fight inflammation go hand in hand with optimizing your wellness. Learn more about fighting chronic inflammation through diet, lifestyle, and very specific types of fasting. A licensed CN Certified Nutritionist can help integrate your nutrition care plan as part of your medical team.
Annette Marsden, M.S., C.N. 360.376.6745 hometownnutrition.com
REFERENCES
- Fernández-Real JM, Pickup JC. Innate immunity, insulin resistance and type 2 diabetes. Diabetologia. 2012 Feb;55(2):273-8.
- Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010 Mar 19;140(6):883-99.
- Dregan A, Chowienczyk P, Gulliford MC. Are Inflammation and Related Therapy Associated with All-Cause Dementia in a Primary Care Population? J Alzheimers Dis. 2015;46(4):1039-47
- Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Jan;19(1):11-38.
- Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003 Dec;112(12):1796-808.
- Esmaillzadeh A, Kimiagar M, Mehrabi Y, et al. Dietary patterns and markers of systemic inflammation among Iranian women. J Nutr. 2007; 137:992–998. [PubMed: 17374666]
- Turner-McGrievy GM, Wirth MD, Shivappa N, et al. Randomization to plant-based dietary approaches leads to larger short-term improvements in dietary inflammatory index scores and macronutrient intake compared with diets that contain meat. Nutr Res. 2015;35(2):97–106. [PubMed]
- Chrysohoou C, Panagiotakos DB, Pitsavos C, et al. Adherence to the Mediterranean diet attenuates
inflammation and coagulation process in healthy adults: the ATTICA Study. J Am Coll Cardiol.
2004; 44:152–158. [PubMed: 15234425] - Shivappa N, Steck SE, Hurley TG, et al. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr [Internet]. 2014;17(8):1689–1696. Available from:http://www.journals.cambridge.org/abstract_S1368980013002115[PMC free article] [PubMed]
Henson J, Yates T, Edwardson C, et al. Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population. Published online 2013 Oct 29. doi: 10.1371/journal.pone.0078350
Shiels MS, Katki HA, Freedman ND, et al. Cigarette smoking and variations in systemic immune and inflammation markers. J Natl Cancer Inst. 2014 Oct 1;106(11).
- van den Hooven EH, de Kluizenaar Y, Pierik FH, et al. Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R Study. Environ Health Perspect. 2012 May;120(5):746-51.
Chemical pneumonitis https://medlineplus.gov/ency/article/000143.htm
Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol. 2014 Sep;222(3):R113-27
- Herbert Tilg and Alexander R Moschen. Inflammatory Mechanisms in the Regulation of Insulin Resistance. Mol Med. 2008 Mar-Apr; 14(3-4): 222–231.
Plaque Psoriasis – National Library of Medicine – PubMed Health https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0022696/
Ulcerative Colitis – National Library of Medicine – PubMed Health https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0022830/
- Bergmans RS, Malecki KM. The association of dietaryinflammatory potential with depression and mental well-being among U.S. adults. Prev Med. 2017 Jun;99:313-319. PMID: 28342730.
- Naitza S, Porcu E, Steri Mm et al. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 2012 Jan;8(1):e1002480. doi: 10.1371/journal.pgen.1002480. PMID:22291609
- Ferreira RC, Freitag DF, Cutler AJ, et, al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 2013 Apr;9(4):e1003444. doi: 10.1371/journal.pgen.1003444. PMID:23593036